Lipid Signaling Laboratory
- B.S., 1974, University of Zaragoza, Spain
- B.S., 1977, University of Barcelona, Spain
- M.S., 1978, University of Barcelona, Spain
- Ph.D., University of Barcelona, Spain, 1981
Department of Molecular Genetics, University of Texas Health Science Center at Dallas, 1982-1988
The overall interest of this laboratory is the regulation of cholesterol and bile acid metabolism. Conversion of cholesterol to bile acids is one of the major mechanisms that mammals have to eliminate cholesterol. Excess cholesterol is a risk factor in cardiovascular diseases, such as atherosclerosis and others. Two lines of studies are currently active in the lab. First, we are studying the molecular mechanisms involved in the bile acid-mediated regulation of the transcription of the cholesterol 7α-hydroxylase and 12 α-hydroxylase genes by the family of transcriptional factors known as nuclear receptors. The second line of studies relates to the role of StarD4 and StarD5 in the intracellular movement of cholesterol. These two proteins are members of a large family of proteins, known as START-related lipid transfer proteins that bind cholesterol inside the cells to transport it to different subcellular organelles. These Start proteins play key roles in maintaining cell integrity and overall cholesterol homeostasis. We use tissue culture systems, transgenic mice technology, and in vitro approaches.