The architectural and cellular complexity of the nervous system reflects its staggering array of functions. This includes not only behavior and cognition, but also the orchestration and maintenance of vital functions and the integration of sensory signals that allow us to respond to the environment.
Neuroscience researchers in the Department of Biochemistry and Molecular Biology employ a variety of state-of-the-art techniques and models to investigate the cellular and molecular mechanisms that control nervous system formation and function under both normal and pathological conditions, with a focus on both neuronal and different glial cell populations. The ultimate goal of these studies is to provide important insights into novel treatments for nervous system disorders.
Our major areas of research include the following:
- The developing and aging brain
- The biology of astrocytes and their function as regulators of neuronal connectivity
- Oligodendrocyte generation and myelin membrane formation
- Demyelinating diseases such as multiple sclerosis
- Roles of the endogenous opioid system and opioid addiction effects on brain development
- Cellular and molecular mechanisms of pain control
- Brain cancer biology and treatment development
Paul Dent, Ph.D.
Tomasz Kordula, Ph.D.
Carmen Sato-Bigbee, Ph.D.
Sandeep Singh, Ph.D.
Sarah Spiegel, Ph.D.
Brian Wattenberg, Ph.D.